期刊
THORAX
卷 74, 期 5, 页码 496-499出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/thoraxjnl-2018-212609
关键词
-
资金
- French Ministry of Health [PHRC-I 2010-06]
- French National Research Agency in the framework of the 'Investissements d'avenir' programme [ANR-15-IDEX-02]
Systemic inflammation and metabolic disorders are among the mechanisms linking obstructive sleep apnoea (OSA) and cardiovascular disease (CVD). In 109 patients with severe OSA and no overt CVD, biomarkers of inflammation (C reactive protein, interleukin-6, tumour necrosis factor-a and its receptors, adiponectin, leptin and P-selectin), glucose and lipid metabolism, and N-terminal pro-brain natriuretic peptide, were measured before and after 2 months of treatment with a mandibular advancement device (MAD) (n=55) or a sham device (n=54). MAD reduced the Apnoea-Hypopnoea Index (p<0.001) but had no effect on circulating biomarkers compared with the sham device, despite high treatment adherence (6.6 hour/night).
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