期刊
THORAX
卷 74, 期 4, 页码 413-416出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/thoraxjnl-2018-212021
关键词
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资金
- Arthritis Research Career Development Fellowship [20629]
- Asthma UK Senior Clinical Academic Development Award [AUK-SCAD-2013-229]
- MRC [MR/L006499/1]
- Wellcome Trust [107851/Z/15/Z]
- MRC [MR/P023576/1, MR/P023576/2, MR/L006499/1, G0601556] Funding Source: UKRI
The importance of circadian factors in managing patients is poorly understood. We present two retrospective cohort studies showing that lungs reperfused between 4 and 8 AM have a higher incidence (OR 1.12; 95% CI 1.03 to 1.21; p=0.01) of primary graft dysfunction (PGD) in the first 72 hours after transplantation. Cooling of the donor lung, occurring during organ preservation, shifts the donor circadian clock causing desynchrony with the recipient. The clock protein REV-ERBa directly regulates PGD biomarkers explaining this circadian regulation while also allowing them to be manipulated with synthetic REV-ERB ligands.
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