期刊
THERAPIE
卷 74, 期 2, 页码 181-185出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.therap.2018.11.001
关键词
Pharmacoepidemiology; Observational studies; Level of evidence; Biases; Net benefit
After looking at some case studies, we will remind in this paper how observational studies regarding drug exposure or delivery are prone to various biases and structural limitations. These biases lead us to be extremely cautious regarding the implementation of results from such studies in clinical practice, and to question the reliability of such studies to determine the position of a given treatment into the therapeutic strategy. We will conclude on the respective place of randomized controlled trials (RCTs) and observational approaches, which are obviously complementary, but not interchangeable. (C) 2018 Societe francaise de pharmacologie et de therapeutique. Published by Elsevier Masson SAS.
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