期刊
TETRAHEDRON LETTERS
卷 60, 期 7, 页码 547-551出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2019.01.024
关键词
Benzoquinone ansamycin; C5-C15 fragments; Hsp90; C8-diversification
资金
- CAMS Innovation Fund for Medical Sciences [CIFMS 2016-I2M-3-009, CIFMS 2017-I2M-3-011]
- Natural Science Foundation of China [21272279]
Benzoquinone ansamycins are known to be potent Heat shock protein (Hsp90) inhibitors, and total-synthesis-based structure modification of this natural product family may lead to the discovery of novel cancer chemotherapeutics. Described in this paper is a unified synthetic route that gives access to both natural and C-8-modified C5-C15 fragments of this natural product family. (C) 2019 Elsevier Ltd. All rights reserved.
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