期刊
TETRAHEDRON LETTERS
卷 59, 期 51, 页码 4514-4516出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2018.11.024
关键词
Indigofera stachyodes; Stachyodin; Pterocarpan; Anti-inflammatory activity
资金
- National Natural Science Foundation of China [81573572, 81530097]
Stachyodin A (1), a rearrangement product of pterocarpan featuring a 6/5/5/6 tetracyclic ring system with an unusual spirotetrahydrofuran ring, and stachyodin B (2), a new dihydrochalcone, along with five known analogues (3-7) were isolated from the roots of Indigofera stachyodes. The structures of 1 and 2 were elucidated on the basis of their HRESIMS and NMR spectroscopic data, and their absolute configurations were determined by X-ray crystallographic analysis and electronic circular dichroism (ECD) data, respectively. Compounds 2-4 showed inhibition of nitric oxide production in lipopolysaccharide-activated BV-2 microglial cells. (C) 2018 Elsevier Ltd. All rights reserved.
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