期刊
TETRAHEDRON LETTERS
卷 60, 期 2, 页码 147-149出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2018.11.074
关键词
Isoindolinone; [3+3]Benzannulation; 1,3-Bissulfonylpropene; 4-Arylmethylene-2,3-dioxopyrrolidine; 4-Sulfonylcrotonate
资金
- National Natural Science Foundation of China [21472248, 21772240]
- Guangzhou Science Technology and Innovation Commission [201707010210]
A straightforward synthesis of isoindolinones has been developed via a [3 + 3] benzannulation of 4-arylmethylene-2,3-dioxopyrrolidines and 1,3-bissulfonylpropenes (or 4-sulfonylcrotonates). A series of functionalized isoindolinones were obtained in excellent yields. The reaction could be carried out under mild conditions without transition metal catalyst. The finding provides a practical approach for the preparation of isoindolinone derivatives with potential biological activities. (C) 2018 Elsevier Ltd. All rights reserved.
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