期刊
TETRAHEDRON LETTERS
卷 60, 期 10, 页码 703-706出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2019.01.008
关键词
Allenoate; Quinidine; Zwitterion; Arylidenepyrazolones; Tetrahydropyranopyrazole
资金
- Department of Biotechnology, New Delhi [6242-P85/RGCB/PMD/DBT/RJCH/2015]
- CSIR, New Delhi
The enantioselective synthesis of the tetrahydropyranopyrazole scaffold has been achieved. The quinidine catalyzed reaction of allenoates with arylidenepyrazolones proceeded with high enantio- and diastereoselectivity while the reactions of alkylidenepyrazolones were less efficient. Allene ketones also afforded tetrahydropyranopyrazole derivatives in high yields, however, with only moderate enantioselectivity. The primary adduct undergoes further functional group transformations without effecting the initially formed chiral centre. (C) 2019 Elsevier Ltd. All rights reserved.
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