期刊
TETRAHEDRON LETTERS
卷 59, 期 47, 页码 4121-4135出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2018.10.012
关键词
Vinylogous reaction; Direct reaction; Asymmetric catalysis; Organocatalysis; Transition-metal catalysis
资金
- Thousand Youth Talents Plan
- National Natural Science Foundation of China [21672235, 21871287, 21576230]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
- CAS Key Laboratory of Synthetic Chemistry of Natural Substances
- Shanghai Institute of Organic Chemistry
Direct catalytic asymmetric vinylogous reaction serves as a powerful tool to introduce stereocenter(s) at the gamma- or/and even more remote position(s) of the vinylogous products in an atom-economical and efficient way. A variety of direct catalytic asymmetric vinylogous reactions with broad substrate scope and mild reaction conditions has been developed. Both metal catalysis and organocatalysis contributed in this field and led to the vinylogous products in high stereoselectivity. These vinylogous reactions provided efficient pathways for the synthesis of highly functionalized optically pure compounds, especially these with potential biological activity and pharmacological activity. This digest paper mainly focuses on the most recent developments in this field, including both nucleophilic addition and nucleophilic substitution. (C) 2018 Elsevier Ltd. All rights reserved.
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