期刊
TETRAHEDRON
卷 75, 期 8, 页码 1072-1078出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2019.01.014
关键词
3,4-Dihydroquinazoline; 4,5-Dihydro-3H-1,4-benzodiazepin-3-one; Ugi reaction; Standinger reaction; Aza-Wittig reaction
资金
- National Natural Science Foundation of China [21572075]
- 111 Project [B17019]
An efficient one-pot and regioselective synthesis of 3,4-dihydroquinazolines and 4,5-dihydro-3H-1,4-benzodiazepin-3-ones by Ugi/Staudinger/aza-Wittig sequence has been developed. The Ugi reactions of 2-azidobenzylamines, aldehydes, acids (or alpha-keto acids) and isocyanides produced the azide intermediates, which were then treated with tributylphosphine or triphenylphosphine to give poly-substituted 3,4-dihydroquinazolines or 4,5-dihydro-3H-1,4-benzodiazepin-3-ones in moderate to good yields by tandem Standinger/aza-Wittig reactions. (C) 2019 Elsevier Ltd. All rights reserved.
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