期刊
TETRAHEDRON
卷 74, 期 50, 页码 7173-7178出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2018.10.048
关键词
Structure-activity relationship; Thallusin; Marine algae; Synthesis; Tandem cyclization
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of the Japanese Government [26460026, 18K05365]
- Adaptable and Seamless Technology Transfer Program through Target -driven R&D (A-STEP) of Japan Science and Technology Agency (JST) [AS231Z01199E]
Thallusin is the only known natural product that induces cell differentiation followed by formation of a thallus during the growth of green macroalgae such as Monostroma and Ulva. Herein, various thallusin analogues based on the terpen skeleton were synthesized to study the structure-activity relationships of thallusin. The potency of the synthetic analogues was investigated in an experimental assay, which demonstrated that the 19-methyl group in thallusin is essential for potent morphogenesis-inducing activity. (C) 2018 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据