期刊
TETRAHEDRON
卷 74, 期 50, 页码 7111-7119出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2018.10.017
关键词
Vinyl nosylates; Sonogashira; para-Nitrobenzenesulfonate; Cross-coupling; Palladium
资金
- French Ministry of Research
- CNRS
- French Agency of Research [ANR 09-BLAN-0329 CADISCOM]
Vinyl nosylates, readily obtained from beta-dicarbonyl derivatives, could be efficiently engaged in Sonogashira cross-coupling reactions, either cocatalyzed by copper or silver salts. The para-nitro-benzenesulfonate (nosylate) group allows this coupling to be performed under very mild conditions (room temperature). These new leaving group and mild conditions could be applied to the synthesis of acetylenic coumarinyl derivatives and to the total synthesis of an acetylenic monoterpene natural product, named cleviolide. (C) 2018 Elsevier Ltd. All rights reserved.
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