期刊
TETRAHEDRON
卷 75, 期 12, 页码 1689-1696出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2018.11.016
关键词
Organocatalytic; Quinones; 3-Isothiocyanato oxindoles; Pyrrolidonyl spirooxindoles; Stereocontrol
资金
- National Natural Science Foundation of China [21772081]
- Shenzhen Special Funds for the Development of Biomedicine, Internet, New Energy, and New Material Industries [JCYJ20170412151701379]
- Southern University of Science and Technology [K01211007]
Quinones, precursors of aromatic structures, were firstly employed as the electrophiles for the organocatalytic Michael addition/cyclization cascade reaction with versatile 3-isothiocyanato oxindoles. Chiral bifunctional organocatalyst was appropriate for this enantioselective transformation to afford a variety of novel spirooxindoles, possessing a spirocyclic stereocenter adjacent to the aromatic ring, via asymmetric double arylation. These synthesized spirooxindoles are very difficult to access by the reported methods and were obtained in excellent chemical yields with excellent enantioselectivities. (C) 2018 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据