期刊
TETRAHEDRON
卷 75, 期 12, 页码 1663-1668出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2018.11.045
关键词
2-Alkynylbenzoic acid; Isobenzofuran-1(3H)-one; Bromocyclization; Regioselective
资金
- Natural Science Foundation of China [21502069, 21772067]
- China Postdoctoral Science Foundation [2018M630396]
A direct synthesis of 3-(bromomethylene)isobenzofuran-1(3H)-ones from 2-alkynylbenzoic acids is developed through a regioselective 5-exo-dig bromocyclization. The reaction proceeds smoothly with a broad substrate scope. The products can be further elaborated via a palladium-catalyze cross-coupling reaction, or can convert to other heterocycles through simple operation. Preliminary mechanistic studies reveal that this transformation undergoes a radical process. (C) 2018 Elsevier Ltd. All rights reserved.
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