Directed C-H Functionalization of the Adamantane Framework

This review summarizes the synthetic approaches towards 1,2-substitution pattern on the adamantane framework. Selected are the works containing the directed C-H functionalization step. 1 Introduction 2 Access to 1,2-Disubstituted Derivatives via C-H Insertion Reactions of Electrophilic Organic Species 3 Access to 1,2-Disubstituted Derivatives through Hydrogen Radical Abstraction Reactions 4 Access to 1,2-Disubstituted Derivatives Exploiting Metal-Catalyzed (Promoted) C-H Activations 5 Access to 1,2-Disubstituted Derivatives via Hydride Shift 6 Conclusion 7 Acronyms