期刊
SURFACE & COATINGS TECHNOLOGY
卷 358, 期 -, 页码 266-275出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.surfcoat.2018.11.037
关键词
Calcium phosphate; Titanium; Coating; Pulse electrodeposition; Antibacterial agent; Characterization
资金
- Catalan Agency for Management of University and Research Grants (AGAUR FI-DRG) (Catalan Government) [SGR2014 01333, SGR 2017 SGR1165]
- BIOACTISURF project of Midi-Pyrenees Region [14054394]
- COST Action Ipromedai [TD1305]
- Spanish goverment (MINECO/FEDER) [MAT2015-67183-R]
- EU through European Regional Development Funds
Metallic implants have some limitations related to bioactivity and bacteria colonization leading to infections. In this regard, calcium phosphate coatings can be used as carrier for drug delivery in order to improve the mentioned drawbacks. The present work proposes the introduction of an antibacterial agent in the course of a pulsed and reverse pulsed electrodeposition. Calcium phosphate coatings were prepared in 30 min using different pulse waveforms (unipolar-bipolar), current densities (2-5 mA/cm(2)) and temperatures (40-60 degrees C). Mechanical stability of the as-coated surfaces was studied in order to select the optimal electrodeposition conditions. Subsequently, selected coatings were loaded with an antiseptic agent, chlorhexidine digluconate (CHX), via a single-step co-deposition procedure. CHX concentration added to the electrolyte was adjusted to 3 mM based on the antibacterial efficacy of the loaded coatings evaluated in vitro with Staphylococcus aureus and Escherichia coli bacteria strains. Whereas the same chlorhexidine concentration was added to the electrolyte, results showed that the amount of CHX loaded was different for each condition while release kinetics was maintained. The results of this work demonstrate that a pulsed co-deposition strategy has great potential to modulate local delivery of antibacterial agents such as chlorhexidine digluconate, which may prevent early phase infections of metallic implants after insertion.
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