期刊
STEM CELLS
卷 37, 期 1, 页码 14-25出版社
OXFORD UNIV PRESS
DOI: 10.1002/stem.2922
关键词
Stem cells; Intercellular communication; Organelle transfer; Mitochondria; Lysosomes; Tunneling nanotubules; Extracellular vesicles; Cellular fusion
资金
- MRC CiC [MR/R025096/1]
- MRC [MR/R025096/1, MR/L017229/1] Funding Source: UKRI
The therapeutic potential of stem cell-based therapies may be largely dependent on the ability of stem cells to modulate host cells rather than on their differentiation into host tissues. Within the last decade, there has been considerable interest in the intercellular communication mediated by the transfer of cytoplasmic material and organelles between cells. Numerous studies have shown that mitochondria and lysosomes are transported between cells by various mechanisms, such as tunneling nanotubes, microvesicles, and cellular fusion. This review will focus on the known instances of organelle transfer between stem cells and differentiated cells, what effects it has on recipient cells and how organelle transfer is regulated. Stem Cells 2019;37:14-25
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