期刊
SOUTH AFRICAN JOURNAL OF BOTANY
卷 119, 期 -, 页码 318-324出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.sajb.2018.10.006
关键词
Neuroprotection; SH-SY5Y cells; Acetylcholinesterase inhibition; Halophytes
资金
- National Research Council of Argentina(CONICET)
- Universidad Nacional del Sur (Argentina)
- Universidad de La Laguna, Tenerife
Halophyte plants have to survive in a hostile environment by developing adaptive responses. One of these strategies is the production of several protective molecules which make these plants an interesting source of bioactive compounds. Significant acetylcholinesterase inhibition was observed for ethanolic extracts obtained from Lippia salsa Griseb. (Verbenaceae) and Moeda bidentis (L.) Kuntze (Asteraceae), two plants that are widely distributed in the salt marsh Salitral de la Vidriera These results encouraged us to further study the active constituents and the potential neuroprotective properties of these plants. The flavonoids luteolin (1) and apigenin (2) were identified as the active components of L. salsa, while 6-methoxykaempferol-3-sulfate (3) was obtained from F. bidentis. In addition, we investigated the cytotoxicity, cellular protection against K+-depolarization and antioxidant activity in SH-SY5Y neuroblastoma cells for these extracts and compound 3. Results demonstrated that beyond acting as acetylcholinesterase inhibitors, they also exhibited neuroprotective effects against KCl-induced-Ca2+ overload and oxidative stress. (C) 2018 SAAB. Published by Elsevier B.V. All rights reserved.
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