期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1852, 期 9, 页码 1887-1894出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2015.06.019
关键词
Adiponectin; Cerebrovascular diseases; Neurodegenerative diseases
资金
- National Natural Science Foundation of China [81222015]
- Excellent Doctoral Support Project of the Fourth Military Medical University [2013D01]
- New Century Talent Supporting Project by the Chinese Ministry of Education [NCET-12-1004]
Adiponectin is an anti-atherogenic protein secreted by adipose cells that improves insulin sensitivity. Notably, adiponectin receptors are expressed in the brain, suggesting that adiponectin signaling disruption may impact neurologic function. Recently, studies have demonstrated the association of adiponectin levels with cerebrovascular disorders and neurodegenerative diseases (NDDs), and these results have drawn significant attention. In this review, we discuss the association between the adiponectin levels and the incidence, progression, and prognosis of cerebrovascular disorders and NDDs. We describe the controversial issues surrounding current studies and present our hypothesis concerning the possible mechanism underlying adiponectin function in neurological disorders. Finally, we explicate obstacles preventing clinical adiponectin administration, including available routes of drug delivery and the central nervous system regulation of adiponectin. Collectively, the data assembled herein serve as a comprehensive reference regarding the role of adiponectin in neurological disorders to support the future clinical potential of adiponectin as a therapeutic agent. (C) 2015 Elsevier B.V. All rights reserved.
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