期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1851, 期 8, 页码 1052-1065出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2014.12.014
关键词
Fatty acid; Glycerolipid; Glycerophospholipid; Sphingolipid; Major depression; Anxiety disorder
资金
- Deutsche Forschungsgemeinschaft [GU 335/29-1, KO 947/13-1]
- Interdisciplinary Center for Clinical Research Erlangen, Forschungsstiftung Medizin at the University Hospital Erlangen [E13]
- Scholarship Programme 'Equality for Women in Research and Teaching', University Erlangen-Nuremberg
- Annika Liese Price
Major depression and anxiety disorders have high prevalence rates and are frequently comorbid. The neurobiological bases for these disorders are not fully understood, and available treatments are not always effective. Current models assume that dysfunctions in neuronal proteins and peptide activities are the primary causes of these disorders. Brain lipids determine the localization and function of proteins in the cell membrane and in doing so regulate synaptic throughput in neurons. Lipids may also leave the membrane as transmitters and relay signals from the membrane to intracellular compartments or to other cells. Here we review how membrane lipids, which play roles in the membrane's function as a barrier and a signaling medium for classical transmitter signaling, contribute to depression and anxiety disorders and how this role may provide targets for lipid-based treatment approaches. Preclinical findings have suggested a crucial role for the membrane-forming n-3 polyunsaturated fatty acids, glycerolipids, glycerophospholipids, and sphingolipids in the induction of depression- and anxiety-related behaviors. These polyunsaturated fatty acids also offer new treatment options such as targeted dietary supplementation or pharmacological interference with lipid-regulating enzymes. While clinical trials support this view, effective lipid-based therapies may need more individualized approaches. Altogether, accumulating evidence suggests a crucial role for membrane lipids in the pathogenesis of depression and anxiety disorders; these lipids could be exploited for improved prevention and treatment This article is part of a Special Issue entitled Brain Lipids. (C) 2014 The Authors. Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据