期刊
SENSORS
卷 18, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/s18124281
关键词
cholinesterase; mutant; organophosphorus pesticides; sensor
资金
- National Key Research and Development Program of China [2017YFA0505200]
- National Natural Science Foundation of China [21672079]
- Hubei Province Natural Science Foundation [2018CFA072]
- self-determined research funds of Central China Normal University from the colleges' basic research and operation of MOE [CCNU18ZDPY01, CCNU18TS007]
Nowadays, pesticide residues constitute an increasing public health concern. Cholinesterases, acetylcholinesterase, and butyrylcholinesterase, are reported to be involved in detoxification processes owing to their capability of scavenging organophosphates and carbamates. Thus, these enzymes are targeted for the discovery of sensors aiming at detecting pesticide residues. In recent years, cholinesterase-based biosensors have attracted more and more attention in the detection of pesticides. Herein, this review describes the recent progress on the engineering of cholinesterases and the development of the corresponding sensors that could be used for the detection of organophosphorus pesticide residues.
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