Public health applications of CRISPR: How children's health can benefit

Children under the age of five years old face significant mortality risks around the world. Public health innovations, particularly gene-editing technologies such as clustered regularly interspaced short palindromic repeats (CRISPR) could help to reduce the risk of death in children under the age of five years old. For example, CRISPR-based strategies could reduce infectious disease morbidity by gene editing mosquitoes to prevent transmission of malaria. CRISPR gene editing technology could also help to screen for influenza virus and prevent it from replicating; influenza is a particularly difficult to treat and severe virus causing many deaths in children. The lack of liver, kidney, and heart donations for children on the organ donation waiting list could also benefit from CRISPR. Gene editing of pigs to reduce rejection rates and associated risks of porcine endogenous retroviruses could allow for the utilization of pig organs for transplant. Here we review proposed applications of gene-editing technology in public health and discuss its potential to reduce child mortality and morbidity globally. (C) 2018 Elsevier Inc. All rights reserved.