期刊
SEMINARS IN CANCER BIOLOGY
卷 57, 期 -, 页码 79-85出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2018.11.001
关键词
KDM5B; H3K4me3; Embryonic stem cells; Cancer; Pluripotent; Epigenetics; Chromatin; Gene expression; Differentiation; Histone demethylase
类别
资金
- Wayne State University, Karmanos Cancer Institute
- National Heart, Lung and Blood Institute [1K22HL126842-01A1]
- Elsa U. Pardee Foundation
Epigenetic regulation of chromatin plays a critical role in controlling stem cell function and tumorigenesis. The histone lysine demethylase, KDM5B, which catalyzes the demethylation of histone 3 lysine 4 (H3K4), is important for embryonic stem (ES) cell differentiation, and is a critical regulator of the H3K4-methylome during early mouse embryonic pre-implantation stage development. KDM5B is also overexpressed, amplified, or mutated in many cancer types. In cancer cells, KDM5B regulates expression of oncogenes and tumor suppressors by modulating H3K4 methylation levels. In this review, we examine how KDM5B regulates gene expression and cellular fates of stem cells and cancer cells by temporally and spatially controlling H3K4 methylation levels.
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