期刊
SEMINARS IN CANCER BIOLOGY
卷 53, 期 -, 页码 156-167出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2018.11.006
关键词
Cancer stem cells; Dormancy; EMT; DNA repair; Stem cell niche
类别
资金
- Austrian Science Fund (FWF) [P29457]
- Anniversary Fund of Austrian National Bank [ONB 17620]
- Ingrid Shaker-Nessmann Cancer Research Foundation
- Austrian Science Fund (FWF) [P29457] Funding Source: Austrian Science Fund (FWF)
Cancer stem cells (CSC) possess abilities generally associated with embryonic or adult stem cells, especially self renewal and differentiation. The CSC model assumes that this subpopulation of cells sustains malignant growth, which suggests a hierarchical organization of tumors in which CSCs are on top and responsible for the generation of intratumoral heterogeneity. Effective tumor therapy requires the eradication of CSC as they can support regrowth of the tumor resulting in recurrence. However, eradication of CSC is difficult because they frequently are therapy resistant. Therapy resistance is mediated by the acquisition of dormancy, increased DNA repair and drug efflux capacity, decreased apoptosis as well as the interaction between CSC and their supporting micro-environment, the CSC niche. This review highlights the role of CSC in chemo- and radiotherapy resistance as well as possible ways to overcome CSC mediated therapy resistance.
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