期刊
SEMINARS IN CANCER BIOLOGY
卷 58, 期 -, 页码 90-99出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2018.12.002
关键词
circRNA; Biomarkers; Liquid biopsies; Non-coding RNA
类别
资金
- IKERBASQUE foundation for science
- Starmer-Smith memorial fund
- Ministerio de Economia y Competitividad (MINECO) of the Spanish Central Government
- FEDER funds [PI12/00663, PIE13/00048, DTS14/00109, PI15/00275]
- Departamento de Desarrollo Economic y Competitividad y Departamento de Sanidad of the Basque government
- Asociacion Espanola Contra el Cancer (AECC)
- Diputacion Foral de Guipuzcoa (DFG)
Circular RNAs (circRNAs) are a novel class of regulatory RNAs that despite being relatively abundant have only recently begun to be explored. There are many thousands of genes that appear capable of producing circRNAs, however the function of all but a handful remain to be determined. What is emerging about these highly conserved molecules is that they play important roles in biology and cancer biology in particular. The most explored function of circRNAs is as master regulators of gene expression that act to sequester or 'sponge' other gene expression regulators, in particular miRNAs. They have also been demonstrated to function via direct modulation of transcription, and by interfering with splicing mechanisms. Although generally expressed in low abundance when compared to their linear counterparts, they are often expressed in a tissue- and developmental stage-specific manner. Coupled with their remarkable resistance to RNAse activity due to a covalent closed cyclic structure, circRNAs show great promise as novel biomarkers of cancer and other diseases. In this review we consider the current state of knowledge regarding these molecules, their synthesis, function, and association with cancer. We will also review some of the challenges that remain to be resolved if this emerging class of RNAs are really to become useful in the clinic.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据