相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Monomeric TCRs drive T cell antigen recognition
Mario Brameshuber et al.
NATURE IMMUNOLOGY (2018)
Early T cell receptor signals globally modulate ligand: receptor affinities during antigen discrimination
Rafal M. Pielak et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Therapeutic Potential of T Cell Chimeric Antigen Receptors (CARs) in Cancer Treatment: Counteracting Off-Tumor Toxicities for Safe CAR T Cell Therapy
Gideon Gross et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 56 (2016)
Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS
William Y. C. Huang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Phase separation of signaling molecules promotes T cell receptor signal transduction
Xiaolei Su et al.
SCIENCE (2016)
The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters
Lakshmi Balagopalan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime
Dibyendu Kumar Das et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui et al.
JOURNAL OF IMMUNOLOGY (2015)
Liquid-Liquid Phase Separation in Biology
Anthony A. Hyman et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)
Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance
Ondrej Stepanek et al.
CELL (2014)
Accumulation of Serial Forces on TCR and CD8 Frequently Applied by Agonist Antigenic Peptides Embedded in MHC Molecules Triggers Calcium in T Cells
Sergey Pryshchep et al.
JOURNAL OF IMMUNOLOGY (2014)
Size-Based Chromatography of Signaling Clusters in a Living Cell Membrane
Nina G. Caculitan et al.
NANO LETTERS (2014)
Organizing MHC class II presentation
David R. Fooksman
FRONTIERS IN IMMUNOLOGY (2014)
The Transcription Factor NFAT Exhibits Signal Memory during Serial T Cell Interactions with Antigen-Presenting Cells
Francesco Marangoni et al.
IMMUNITY (2013)
A Single Peptide-Major Histocompatibility Complex Ligand Triggers Digital Cytokine Secretion in CD4+ T Cells
Jun Huang et al.
IMMUNITY (2013)
Major Histocompatibility Complex (MHC) Class II-Peptide Complexes Arrive at the Plasma Membrane in Cholesterol-rich Microclusters
Berta Bosch et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Modulation of T cell signaling by the actin cytoskeleton
Yan Yu et al.
JOURNAL OF CELL SCIENCE (2013)
The Ability of Sos1 to Oligomerize the Adaptor Protein LAT Is Separable from Its Guanine Nucleotide Exchange Activity in Vivo
Robert L. Kortum et al.
SCIENCE SIGNALING (2013)
Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells
Geoff P. O'Donoghue et al.
ELIFE (2013)
T cell receptor signalling networks: branched, diversified and bounded
Rebecca J. Brownlie et al.
NATURE REVIEWS IMMUNOLOGY (2013)
Receptor Signaling Clusters in the Immune Synapse
Michael L. Dustin et al.
ANNUAL REVIEW OF BIOPHYSICS, VOL 41 (2012)
Determination of Interaction Kinetics between the T Cell Receptor and Peptide-Loaded MHC Class II via Single-Molecule Diffusion Measurements
Markus Axmann et al.
BIOPHYSICAL JOURNAL (2012)
Myosin IIA Modulates T Cell Receptor Transport and CasL Phosphorylation during Early Immunological Synapse Formation
Yan Yu et al.
PLOS ONE (2012)
Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters
Xiuju Lu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Strength of TCR-Peptide/MHC Interactions and In Vivo T Cell Responses
Emily Corse et al.
JOURNAL OF IMMUNOLOGY (2011)
Mass Spectrometry Analysis and Quantitation of Peptides Presented on the MHC II Molecules of Mouse Spleen Dendritic Cells
Leonia Bozzacco et al.
JOURNAL OF PROTEOME RESEARCH (2011)
Logic-Based Models for the Analysis of Cell Signaling Networks
Melody K. Morris et al.
BIOCHEMISTRY (2010)
Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time
Milos Aleksic et al.
IMMUNITY (2010)
Class I MHC molecules as probes of membrane patchiness: from biophysical measurements to modulation of immune responses
Michael Edidin
IMMUNOLOGIC RESEARCH (2010)
TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity
Johannes B. Huppa et al.
NATURE (2010)
Spatial organization and signal transduction at intercellular junctions
Boryana N. Manz et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Designing customized cell signalling circuits
Wendell A. Lim
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Altered Actin Centripetal Retrograde Flow in Physically Restricted Immunological Synapses
Cheng-han Yu et al.
PLOS ONE (2010)
Fast on-rates allow short dwell time ligands to activate T cells
Christopher C. Govern et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Attenuated T Cell Responses to a High-Potency Ligand In Vivo
Emily Corse et al.
PLOS BIOLOGY (2010)
Aggregation of Membrane Proteins by Cytosolic Cross-Linkers: Theory and Simulation of the LAT-Grb2-SOS1 System
Ambarish Nag et al.
BIOPHYSICAL JOURNAL (2009)
Bayesian Single-Exponential Kinetics in Single-Molecule Experiments and Simulations
Daniel L. Ensign et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2009)
Cluster size regulates protein sorting in the immunological synapse
Nina C. Hartman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper
Ed Palmer et al.
NATURE REVIEWS IMMUNOLOGY (2009)
Both MHC class II and its GPI-anchored form undergo hop diffusion as observed by single-molecule tracking
Yasuhiro M. Umemura et al.
BIOPHYSICAL JOURNAL (2008)
T cell receptor microcluster transport through molecular mazes reveals mechanism of translocation
Andrew L. DeMond et al.
BIOPHYSICAL JOURNAL (2008)
Kinetic control of histidine-tagged protein surface density on supported lipid bilayers
Jeffrey A. Nye et al.
LANGMUIR (2008)
Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity
Zhengyu Ma et al.
PLOS BIOLOGY (2008)
A constant affinity threshold for T cell tolerance
Dieter Naeher et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Digital NFATc2 Activation per Cell Transforms Graded T Cell Receptor Activation into an All-or-None IL-2 Expression
Miriam Podtschaske et al.
PLOS ONE (2007)
T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster
Rajat Varma et al.
IMMUNITY (2006)
Phase I trial of the trifunctional anti-HER2 x anti-CD3 antibody ertumaxomab in metastatic breast cancer
Philipp Kiewe et al.
CLINICAL CANCER RESEARCH (2006)
Cholesterol depletion induces solid-like regions in the plasma membrane
SY Nishimura et al.
BIOPHYSICAL JOURNAL (2006)
Anti-CD3 x anti-epidermal growth factor receptor (EGFR) bispecific antibody redirects T-cell cytolytic activity to EGFR-positive cancers in vitro and in an animal model
U Reusch et al.
CLINICAL CANCER RESEARCH (2006)
Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1
Jon C. D. Houtman et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76
T Yokosuka et al.
NATURE IMMUNOLOGY (2005)
Altered TCR signaling from geometrically repatterned immunological synapses
KD Mossman et al.
SCIENCE (2005)
Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling
G Campi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Frequency encoding of T-cell receptor engagement dynamics in calcium time series
C Utzny et al.
BIOPHYSICAL JOURNAL (2005)
T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation
C Sumen et al.
JOURNAL OF CELL BIOLOGY (2004)
Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties
L Malherbe et al.
IMMUNITY (2004)
Programmable cells:: Interfacing natural and engineered gene networks
H Kobayashi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
T cell killing does not require the formation of a stable mature immunological synapse
MA Purbhoo et al.
NATURE IMMUNOLOGY (2004)
Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation
M Krogsgaard et al.
MOLECULAR CELL (2003)
Translational diffusion of individual class II MHC membrane proteins in cells
M Vrljic et al.
BIOPHYSICAL JOURNAL (2002)
Direct observation of ligand recognition by T cells
DJ Irvine et al.
NATURE (2002)
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies
SC Bunnell et al.
JOURNAL OF CELL BIOLOGY (2002)
Clustering of peptide-loaded MHC class I molecules for endoplasmic reticulum export imaged by fluorescence resonance energy transfer
T Pentcheva et al.
JOURNAL OF IMMUNOLOGY (2001)
Quantitation of lysozyme peptides bound to class II MHC molecules indicates very large differences in levels of presentation
C Velazquez et al.
JOURNAL OF IMMUNOLOGY (2001)
分享论文
