期刊
SCIENCE
卷 362, 期 6419, 页码 1186-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aat7925
关键词
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资金
- U.S. Department of Energy, Office of Science, Office of Biological and Environmental Research [DE-AC02-05CH11231]
- National Science Foundation [MCB-1442724, MCB-1715681]
- Miller Institute for Basic Research
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1442724] Funding Source: National Science Foundation
Lipid composition determines the physical properties of biological membranes and can vary substantially between and within organisms. We describe a specific role for the viscosity of energy-transducing membranes in cellular respiration. Engineering of fatty acid biosynthesis in Escherichia coil allowed us to titrate inner membrane viscosity across a 10-fold range by controlling the abundance of unsaturated or branched lipids. These fluidizing lipids tightly controlled respiratory metabolism, an effect that can be explained with a quantitative model of the electron transport chain (ETC) that features diffusion-coupled reactions between enzymes and electron carriers (quinones). Lipid unsaturation also modulated mitochondrial respiration in engineered budding yeast strains. Thus, diffusion in the ETC may serve as an evolutionary constraint for lipid composition in respiratory membranes.
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