期刊
SCIENCE
卷 362, 期 6420, 页码 1301-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aau5445
关键词
-
资金
- Ministry of Education, Culture, Sports, Science, and Technology [15KT0031, 15K07102, 15H059556]
- Advanced Low Carbon Technology Research and Development Program from the Japan Science and Technology Agency
- Japan Society for the Promotion of Science (JSPS)
- Alexander von Humboldt Foundation (AvH)
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- World Premier International Research Center Initiative (WPI), Japan
- Grants-in-Aid for Scientific Research [15KT0031, 15K07102] Funding Source: KAKEN
The parasitic plant Striga hermonthica has been causing devastating damage to the crop production in Africa. Because Striga requires host-generated strigolactones to germinate, the identification of selective and potent strigolactone agonists could help control these noxious weeds. We developed a selective agonist, sphynolactone-7, a hybrid molecule originated from chemical screening, that contains two functional modules derived from a synthetic scaffold and a core component of strigolactones. Cooperative action of these modules in the activation of a high-affinity strigolactone receptor ShHTL7 allows sphynolactone-7 to provoke Striga germination with potency in the femtomolar range. We demonstrate that sphynolactone-7 is effective for reducing Striga parasitism without impinging on host strigolactone-related processes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据