期刊
SCIENCE
卷 362, 期 6411, 页码 181-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aat0473
关键词
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资金
- NIH-NINDS [NS105742, NS089791]
- Hearst Foundation
- Pew Foundation
- Dana Foundation
- CART Foundation
- LouLou Foundation
- Wellcome Trust Senior Research Fellowship [102836/Z/13/Z]
- MRC Project Grant [MR/P006272/1]
- Biogen
- MRC [MR/P006272/1] Funding Source: UKRI
Glia constitute roughly half of the cells of the central nervous system(CNS) butwere long-considered to be static bystanders to its formation and function. Here we provide an overview of how the diverse and dynamic functions of glial cells orchestrate essentially all aspects of nervous system formation and function. Radial glia, astrocytes, oligodendrocyte progenitor cells, oligodendrocytes, and microglia each influence nervous system development, from neuronal birth, migration, axon specification, and growth through circuit assembly and synaptogenesis. As neural circuits mature, distinct glia fulfill key roles in synaptic communication, plasticity, homeostasis, and network-level activity through dynamic monitoring and alteration of CNS structure and function. Continued elucidation of glial cell biology, and the dynamic interactions of neurons and glia, will enrich our understanding of nervous system formation, health, and function.
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