期刊
SCIENCE
卷 363, 期 6422, 页码 43-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aat6280
关键词
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资金
- NIAID Division of Intramural Research [ZIA-AI001115, ZIA-AI001132]
- Division of Intramural Research of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) [ZIA-AR041159, ZIA-AR041167]
- National Psoriasis Foundation Early Career Research Grant
- National Institute of General Medical Sciences (NIGMS) Postdoctoral Research Associate (PRAT) fellowship program
- European Molecular Biology Organization (EMBO) fellowship
- College des Enseignants de Dermatologie Francais
- Philippe Foundation
- Fondation pour la Recherche Medicale
- Societe Francaise de Dermatologie
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI001132, ZICAI001233, ZIAAI001115] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [ZIAAR041159] Funding Source: NIH RePORTER
Barrier tissues are primary targets of environmental stressors and are home to the largest number of antigen-experienced lymphocytes in the body, including commensal-specific T cells. We found that skin-resident commensal-specific T cells harbor a paradoxical program characterized by a type 17 program associated with a poised type 2 state. Thus, in the context of injury and exposure to inflammatory mediators such as interleukin-18, these cells rapidly release type 2 cytokines, thereby acquiring contextual functions. Such acquisition of a type 2 effector program promotes tissue repair. Aberrant type 2 responses can also be unleashed in the context of local defects in immunoregulation. Thus, commensal-specific T cells co-opt tissue residency and cell-intrinsic flexibility as a means to promote both local immunity and tissue adaptation to injury.
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