期刊
RADIOLOGY
卷 290, 期 3, 页码 807-813出版社
RADIOLOGICAL SOC NORTH AMERICA (RSNA)
DOI: 10.1148/radiol.2019182068
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资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [2017R1A2B4008517]
Purpose: To compare the prognostic performances of clinical T categorization between the longest diameter and average diameter at CT in patients who underwent surgical resection of non-small cell lung cancers (NSCLCs). Materials and Methods: This study retrospectively determined clinical T categories based on the longest diameter (clinical T-longest) and average diameter (clinical T-average) in 1153 patients, including 651 men (median age, 67 years; interquartile range [IQR], 60-72 years) and 502 women (median age, 63 years; IQR, 55-70 years) who underwent preoperative chest CT and subsequent resection of NSCLCs (clinical T1 to clinical T4; N0M0) between 2009 and 2015. Prognostic performances for disease-free survival (DFS) were compared between clinical T-longest and clinical T-average by using the Harrell concordance indexes and Student t test. The effect of the average diameter on clinical T category shifts (downstaging) was also investigated by using the McNemar-Bowker test. Results: Concordance indexes did not significantly differ between clinical T-longest (0.72; 95% confidence interval [CI]: 0.67, 0.76) and clinical T-average (0.70; 95% CI: 0.64, 0.75) (P = .12 for the comparison). In the clinical T1 subgroup analysis, concordance indexes were 0.77 (95% CI: 0.71, 0.83) for clinical T-longest and 0.75 (95% CI: 0.69, 0.81) for clinical T-average (P = .17 for the comparison). Use of the clinical T-average resulted in significant downstaging in all clinical T categories (P < .001). Conclusion: The prognostic performance of clinical T categorization was not significantly different between the longest and average diameter measurements. Clinical T categorization based on the longest tumor diameter at CT was demonstrated to be sufficient for risk stratification of surgically treated non-small cell lung cancers. (C) RSNA, 2019
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