期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 289, 期 -, 页码 37-44出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2018.12.004
关键词
Conduct disorder; Structural MRI; Freesurfer; Cortical thickness; Surface area; Fusiform gyms
资金
- Mobilisering mot narkotika (Swedish National Drug Policy Coordinator)
- Stockholm Country Council
- Swedish Foundation for Strategic Research
- VINNOVA
- Swedish Research Council
- Stockholm County Council
- Karolinska Institute
- Stanley Foundation
Among females, conduct disorder (CD) before age 15 is associated with multiple adverse outcomes in adulthood. The few existing structural neuroimaging studies of females with CD report abnormalities of gray matter volumes. The present study compared cortical thickness and surface area of young women with childhood/adolescent CD and healthy women to determine whether cortical abnormalities were present in adulthood and whether they were related to prior CD. Structural brain images from 31 women with CD and 25 healthy women were analyzed using FreeSurfer. Group differences between cortical thickness and surface area were assessed using cluster-wise corrections with Monte Carlo simulations. Women with prior CD, relative to healthy women, showed: (1) reduced cortical thickness in left fusiform gyrus extending up to entorhinal cortex and lingual gyrus; (2) reduced surface area in right superior parietal cortex; (3) increased surface area in left superior temporal gyrus, and right precentral gyrus. These differences remained significant after adjusting for past comorbid disorders, current symptoms of anxiety and depression, current substance use as well as maltreatment. The study suggests that among females, CD prior to age 15 is associated with cortical structure abnormalities in brain regions involved in emotion processing and social interaction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据