期刊
PSYCHIATRY RESEARCH
卷 273, 期 -, 页码 422-429出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2018.12.142
关键词
Schizotypy; Familial schizophrenia; Sporadic schizophrenia; Neurocognition; Paternal age
类别
资金
- ARISTEIA II Action of the Operational Programme Education and Lifelong Learning
- European Social Fund (ESF)
- National Resources [KA2990]
- Special Account for Research of the University of Crete [KA3748]
Studies comparing cognitive processes between familial and sporadic schizophrenia have yielded inconsistent findings. In this study we examined differences in neurocognition and schizotypal traits in unaffected relatives of schizophrenia-spectrum patients with either the familial (multiplex) or the sporadic (simplex) subtype of the disorder, taking paternal age at birth into consideration. Simplex (n = 65; SR), multiplex (n = 35; MR) relatives and controls (n = 114) were compared on several cognitive functions and schizotypal traits; between-group differences were evaluated with and without including paternal age in the analyses. SR and MR had higher negative and paranoid traits compared with controls, but paternal age abolished the differences between the SR and control groups. When taking into account schizotypal traits and participants' age, controls outperformed MR in strategy formation and set-shifting and SR in psychomotor speed, set-shifting and executive working memory. After including paternal age in the analyses, controls outperformed MR in strategy formation, working memory and executive working memory and both groups in psychomotor speed and set-shifting. These findings suggest that multiplex relatives present with a riskier personality and cognitive profile when considering the effects of paternal age. Nevertheless, simplex relatives are impaired in fundamental cognitive processes, thus highlighting the detrimental effects of paternal age on neurocognition.
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