4.3 Article

Interplay of cysteine exposure and global protein dynamics in small-molecule recognition by a regulator of G-protein signaling protein

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Differential Protein Dynamics of Regulators of G-Protein Signaling: Role in Specificity of Small-Molecule Inhibitors

Vincent S. Shaw et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Article Chemistry, Multidisciplinary

Insulin mimetic peptide S371 folds into a helical structure

Hossein Mohammadiarani et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2017)

Article Endocrinology & Metabolism

All-Atom Structural Models of the Transmembrane Domains of Insulin and Type 1 Insulin-Like Growth Factor Receptors

Hossein Mohammadiarani et al.

FRONTIERS IN ENDOCRINOLOGY (2016)

Article Biochemistry & Molecular Biology

Selectivity and Anti-Parkinson's Potential of Thiadiazolidinone RGS4 Inhibitors

Levi L. Blazer et al.

ACS CHEMICAL NEUROSCIENCE (2015)

Review Biochemistry & Molecular Biology

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

Michelle R. Arkin et al.

CHEMISTRY & BIOLOGY (2014)

Article Computer Science, Interdisciplinary Applications

XSEDE: Accelerating Scientific Discovery

John Towns et al.

COMPUTING IN SCIENCE & ENGINEERING (2014)

Review Neurosciences

Development of allosteric modulators of GPCRs for treatment of CNS disorders

Hilary Highfield Nickols et al.

NEUROBIOLOGY OF DISEASE (2014)

Review Pharmacology & Pharmacy

Advances in G Protein-Coupled Receptor Allostery: From Function to Structure

Arthur Christopoulos

MOLECULAR PHARMACOLOGY (2014)

Review Biochemistry & Molecular Biology

Druggable protein-protein interactions - from hot spots to hot segments

Nir London et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2013)

Review Chemistry, Medicinal

Recent Trends and Future Prospects in Computational GPCR Drug Discovery: From Virtual Screening to Polypharmacology

Antonio Carrieri et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2013)

Article Chemistry, Physical

Using collective variables to drive molecular dynamics simulations

Giacomo Fiorin et al.

MOLECULAR PHYSICS (2013)

Review Multidisciplinary Sciences

Molecular signatures of G-protein-coupled receptors

A. J. Venkatakrishnan et al.

NATURE (2013)

Article Multidisciplinary Sciences

Characterization of the free-energy landscapes of proteins by NMR-guided metadynamics

Daniele Granata et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Free-energy landscape of protein oligomerization from atomistic simulations

Alessandro Barducci et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Pharmacology & Pharmacy

A Leap into the Chemical Space of Protein-Protein Interaction Inhibitors

B. O. Villoutreix et al.

CURRENT PHARMACEUTICAL DESIGN (2012)

Review Pharmacology & Pharmacy

Drug discovery for a new generation of covalent drugs

Amit S. Kalgutkar et al.

EXPERT OPINION ON DRUG DISCOVERY (2012)

Article Chemistry, Multidisciplinary

MATCH: An Atom-Typing Toolset for Molecular Mechanics Force Fields

Joseph D. Yesselman et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2012)

News Item Biotechnology & Applied Microbiology

Protein-protein interaction inhibitors get into the groove

Asher Mullard

NATURE REVIEWS DRUG DISCOVERY (2012)

Article Multidisciplinary Sciences

Sampling protein motion and solvent effect during ligand binding

Vittorio Limongelli et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Chemistry, Medicinal

Small Molecule Inhibitors of Regulators of G Protein Signaling (RGS) Proteins

Emma M. Turner et al.

ACS MEDICINAL CHEMISTRY LETTERS (2012)

Article Biochemistry & Molecular Biology

A Nanomolar-Potency Small Molecule Inhibitor of Regulator of G-Protein Signaling Proteins

Levi L. Blazer et al.

BIOCHEMISTRY (2011)

Review Biochemistry & Molecular Biology

Chemical and structural lessons from recent successes in protein-protein interaction inhibition (2P2I)

Xavier Morelli et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Molecular motions in drug design: the coming age of the metadynamics method

Xevi Biarnes et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2011)

Article Pharmacology & Pharmacy

Allosteric Inhibition of the Regulator of G Protein Signaling-Gα Protein-Protein Interaction by CCG-4986

David L. Roman et al.

MOLECULAR PHARMACOLOGY (2010)

Article Pharmacology & Pharmacy

Reversible, Allosteric Small-Molecule Inhibitors of Regulator of G Protein Signaling Proteins

Levi L. Blazer et al.

MOLECULAR PHARMACOLOGY (2010)

Article Physics, Fluids & Plasmas

Metadynamics convergence law in a multidimensional system

Yanier Crespo et al.

PHYSICAL REVIEW E (2010)

Article Biochemistry & Molecular Biology

Differential Modulation of μ- and δ-Opioid Receptor Agonists by Endogenous RGS4 Protein in SH-SY5Y Cells

Qin Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemical Research Methods

Polyplexed Flow Cytometry Protein Interaction Assay: A Novel High-Throughput Screening Paradigm for RGS Protein Inhibitors

David L. Roman et al.

JOURNAL OF BIOMOLECULAR SCREENING (2009)

Article Cardiac & Cardiovascular Systems

RGS4 Regulates Parasympathetic Signaling and Heart Rate Control in the Sinoatrial Node

Carlo Cifelli et al.

CIRCULATION RESEARCH (2008)

Review Physics, Multidisciplinary

Metadynamics: a method to simulate rare events and reconstruct the free energy in biophysics, chemistry and material science

Alessandro Laio et al.

REPORTS ON PROGRESS IN PHYSICS (2008)

Review Chemistry, Multidisciplinary

Scalable molecular dynamics with NAMD

JC Phillips et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2005)

Review Biotechnology & Applied Microbiology

Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream

MR Arkin et al.

NATURE REVIEWS DRUG DISCOVERY (2004)

Article Clinical Neurology

Regulators of G-protein signaling 3 and 4 (RGS3, RGS4) are associated with glioma cell motility

L Tatenhorst et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2004)

Article Multidisciplinary Sciences

Escaping free-energy minima

A Laio et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Review Pharmacology & Pharmacy

Cellular regulation of RGS proteins: Modulators and integrators of G protein signaling

S Hollinger et al.

PHARMACOLOGICAL REVIEWS (2002)

Article Biotechnology & Applied Microbiology

The druggable genome

AL Hopkins et al.

NATURE REVIEWS DRUG DISCOVERY (2002)

Review Biotechnology & Applied Microbiology

Regulators of G-protein signalling as new central nervous system drug targets

RR Neubig et al.

NATURE REVIEWS DRUG DISCOVERY (2002)