期刊
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
卷 140, 期 -, 页码 51-56出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2018.11.016
关键词
2-arachidonoylglyerol; Anandamide; Insulin resistance; Ccardiovascular disease
资金
- Marie Curie Individual Incoming Fellowship [PIIF-GA-2012-332230]
The endocannabinoids anandamide (AEA) and 2-arachidonoylglyerol (2-AG) are endogenous lipid mediators that exert protective roles in pathophysiological conditions, including cardiovascular diseases. In this brief review, we provide a conceptual framework linking endocannabinoid signaling to the control of the cellular and molecular hallmarks, and categorize the key components of endocannabinoid signaling that may serve as targets for novel therapeutics. The emerging picture not only reinforces endocannabinoids as potent regulators of cellular metabolism but also reveals that endocannabinoid signaling is mechanistically more complex and diverse than originally thought.
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