期刊
ACTA DERMATO-VENEREOLOGICA
卷 96, 期 1, 页码 29-34出版社
ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/00015555-2156
关键词
biological markers; melanoma; neoplasm metastasis; microRNAs; REMARK
类别
No specific biomarkers for prognostication or evaluation of tumour load in melanoma have been reported to our knowledge. MicroRNAs (miRNAs) are strongly implicated in oncogenesis and tumour progression, and their circulating forms have been studied as potential biomarkers in oncology. The aim of this prospective study was to identify a melanoma-specific profile of plasma miRNAs. A screening phase, using RNA microarray, was conducted on plasma from 14 patients with metastatic melanoma and 5 healthy subjects. Selected miRNAs were analysed by reverse transcription quantitative PCR (RTqPCR) in 2 independent training and validation cohorts including, respectively, 29 and 31 patients and 16 and 43 control subjects. A profile of 2 miRNAs (miR-1246 and miR-185) significantly associated with metastatic melanoma with a sensitivity of 90.5% and a specificity of 89.1% was identified. This plasma miRNA profile may become an accurate non-invasive biomarker for melanoma.
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