期刊
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
卷 88, 期 -, 页码 112-120出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2018.07.007
关键词
Disorganization; Bipolar disorder; Schizophrenia; Thought disorder; Gyrification; Centrality; Graph theory
资金
- Medical Research Council (UK) [G0601442]
- Canadian Institute of Health Research (Foundation Grant) [375,104]
- Bucke Family Fund
- Academic Medical Organization of South Western Ontario
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [308,775/2015-5, 408,145/2016-1, 310,712/2014-9]
- STIC [AmSud 062/2015]
- FAPESP Center for Neuromathematics [2013/07699-0]
- Boehringer-Ingelheim [270,906, 270,561]
- MRC [G0601442] Funding Source: UKRI
Background: A longstanding notion in the concept of psychosis is the prominence of loosened associative links in thought processes. Assessment of such subtle aspects of thought disorders has proved to be a challenging task in clinical practice and to date no surrogate markers exist that can reliably track the physiological effects of treatments that could reduce thought disorders. Recently, automated speech graph analysis has emerged as a promising means to reliably quantify structural speech disorganization. Methods: Using structural and functional imaging, we investigated the neural basis and the functional relevance of the structural connectedness of speech samples obtained from 56 patients with psychosis (22 with bipolar disorder, 34 with schizophrenia). Speech structure was assessed by non-semantic graph analysis. Results: We found a canonical correlation linking speech connectedness and i) functional as well as developmentally relevant structural brain markers (degree centrality from resting state functional imaging and cortical gyrification index) ii) psychometric evaluation of thought disorder iii) aspects of cognitive performance (processing speed deficits) and iv) functional outcome in patients. Of various clinical metrics, only speech connectedness was correlated with biological markers. Speech connectedness filled the dynamic range of responses better than psychometric measurements of thought disorder. Conclusions: The results provide novel evidence that speech dysconnectivity could emerge from neurodevelopmental deficits and associated dysconnectivity in psychosis.
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