期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 115, 期 46, 页码 E10830-E10838出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1809459115
关键词
fibers; microfluidics; interial focusing; dielectrophoresis; fabrication
资金
- National Science Foundation under the Center for Materials Science and Engineering [DMR-0819762, DMR-1419807]
- US Army Research Laboratory
- US Army Research Office through the Institute for Soldier Nanotechnologies [W911NF-13-D-0001]
- National Institutes of Health [1R21EB022729, 1U24AI118656]
- Defense Advanced Research Projects Agency [N66001-11-1-4182]
- Korea Foundation for Advanced Studies Fellowship
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U24AI118656] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB022729] Funding Source: NIH RePORTER
Traditional fabrication techniques for microfluidic devices utilize a planar chip format that possesses limited control over the geometry of and materials placement around microchannel cross-sections. This imposes restrictions on the design of flow fields and external forces (electric, magnetic, piezoelectric, etc.) that can be imposed onto fluids and particles. Here we report a method of fabricating microfluidic channels with complex cross-sections. A scaled-up version of a microchannel is dimensionally reduced through a thermal drawing process, enabling the fabrication of meters-long microfluidic fibers with nonrectangular cross-sectional shapes, such as crosses, five-pointed stars, and crescents. In addition, by codrawing compatible materials, conductive domains can be integrated at arbitrary locations along channel walls. We validate this technology by studying unexplored regimes in hydrodynamic flow and by designing a high-throughput cell separation device. By enabling these degrees of freedom in microfluidic device design, fiber microfluidics provides a method to create microchannel designs that are inaccessible using planar techniques.
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