期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 115, 期 42, 页码 E9849-E9858出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1714731115
关键词
IL-33/ST2; memory Th2 cell subset; Treg; helminth; allergic inflammation
资金
- Ministry of Education, Culture, Sports, Science and Technology [26221305, 2687072, 17K15675]
- Practical Research Project for Allergic Diseases and Immunology (Research on Allergic Diseases and Immunology) from Japan Agency for Medical Research and Development [JP18ek0410030]
- Japan Agency for Medical Research and Development (AMED)
- Takeda Science Foundation
- Naito Foundation
Memory T helper (mTh) cells play important roles in the reinfection of pathogens and drive the pathogenesis of diseases. While recent studies have characterized the pathogenic mTh2 cell subpopulations driving allergic inflammation, those that induce immune responses against helminth infection remain unknown. We found that IL-5-producing CXCR6(+)ST2(+)CD44(+) mTh2 cells play a crucial role in the IL-33-dependent inhibition of the fecundity of helminth, whereas other ST2(-) mTh2 cells do not. Although both cell types induced the infiltration of granulocytes, especially eosinophils, into the lungs in response to helminth infection, the ST2(+) mTh2 cell-induced eosinophils expressed higher levels of major basic protein (MBP), which is important for reducing the fecundity of Nippostrongylus brasiliensis (Nb), than ST2(-) mTh2 cell-induced ones. Notably, we also found that ST2(+) Treg cells but not ST2(-) Treg cells suppressed CXCR6(+)ST2(+) mTh2 cell-mediated immune responses. Taken together, these findings show that we identified a mechanism against helminth elicited by a subpopulation of IL-5-producing mTh2 cells through the accumulation of eosinophils strongly expressing MBP in the lungs.
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