Stimuli-responsive supramolecular systems guided by chemical reactions

This focus review describes the development of stimuli-responsive supramolecular systems, emphasizing molecular design approach used to construct constituent molecular hybrids comprising chemically reactive small molecules and potentially functional biomolecules or bio-related molecules. The construction of stimuli-responsive supramolecular hydrogels and G-quadruplex-forming nucleic acids, despite the lack of substantial similarity at the supramolecular systems level, highlights the versatile applicability of the molecular design approach for exploring a variety of supramolecular (bio)materials endowed with tailor-made stimuli responsiveness.