ChCl:2ZnCl2 Catalyzed Efficient Synthesis of New Sulfonyl Decahydroacridine-1,8-Diones via One-Pot Multicomponent Reactions to Discover Potent Antimicrobial Agents

A library of new sulfonyl decahydroacridine-1,8-diones has been efficiently synthesized by the one-pot three-component reactions of 4-(p-tolyl sulfonoxy) benzaldehyde, dimedone, and amines in choline chloride-based deep eutectic mixture. Pure target compounds are obtained in very good to excellent yields over short reaction times using straightforward work-up procedure. The synthesized heterocyclic decahydroacridine-1,8-diones were investigated for theirin vitroantimicrobial activity. The minimum inhibitory concentration was determined for the test compounds as well as for reference standards. Compounds4f,4m,4n,and4ohave shown good antibacterial activity whereas compounds4a,4c,4g,4j, and4rhave displayed better antifungal activity.