4.5 Article

Chronic high corticosterone with voluntary corn oil ingestion induces significant body weight gain in mice

期刊

PHYSIOLOGY & BEHAVIOR
卷 204, 期 -, 页码 112-120

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2019.01.004

关键词

Corticosterone; Corn oil ingestion; Brown adipose tissue; Thermogenesis; Obesity

资金

  1. Urakami Foundation
  2. JSPS KAKENHI [16H04924]
  3. Grants-in-Aid for Scientific Research [16H04924] Funding Source: KAKEN

向作者/读者索取更多资源

Corticosterone (CORT) is a powerful regulator of energy metabolism, and chronically high CORT levels cause obesity and diabetes in mice. It is reported that a chronically high CORT level changes food preference, increasing the intake of comfort foods such as fatty foods. Previously, we demonstrated that unlike a high fat diet, voluntary ingestion of 100% pure corn oil increased energy expenditure and thermogenesis through the activation of the interscapular brown adipose tissue (IBAT). In the present study, we investigated whether chronically high CORT affected corn oil intake, energy expenditure, and body weight gain. We delivered CORT to mice via water bottles and placed corn oil in a separate drinking bottle in the home cage. Voluntary corn oil ingestion with CORT induced significant body weight gain, while corn oil ingestion or CORT alone had a modest effect. CORT increased corn oil intake without reducing chow intake, which further increased the total daily caloric intake. CORT suppressed mRNA related to thermogenesis in IBAT. In the hypothalamus, CORT upregulated mRNA expression of the orexigenic neuropeptide, agouti-related protein. These data suggest that chronically high CORT might increase the desire to consume dietary fat, suppressing BAT function, thereby causing obesity.

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