期刊
ACTA BIOMATERIALIA
卷 40, 期 -, 页码 92-99出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2016.05.035
关键词
Electrospun film; PLLA; pSBMA-catechol; Nonfouling; Zwitterionic polymer
资金
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1301435] Funding Source: National Science Foundation
In this work, we modified a hydrophobic electrospun poly (L-lactic) acid (PLLA) film with poly (sulfobetaine methacrylate) (pSBMA)-catechol conjugates of different molecular weights to improve the biocompatibility of the film. These conjugates were synthesized via atom transfer radical polymerization. They consist of an ultra-low fouling pSBMA zwitterionic polymer with a surface-adhesive catechol moiety. X-ray photoelectron spectroscopy, contact angle and scanning electron microscopy experiments were performed to characterize films before and after modification with pSBMA-catechol conjugates. Enzyme-linked immunosorbent and fluorescently-labeled bovine serum albumin were used to study the interactions of proteins with these films. Results showed that low molecular weight zwitterionic pSBMA-catechol conjugates greatly discouraged protein adsorption as shown by use of single protein solutions on PLLA films when the modification was performed in ethanolic Tris-HCl solution. This work offers a convenient and effective method to modify electrospun PLLA films for biomedical applications. Statement of Significance In this work, we report a convenient and effective method to modify electrospun PLLA films using pSBMA-catechol conjugates via graft-to for biomedical applications. After pSBMA modification, the PLLA surface becomes hydrophilic with low contact angle and protein adsorption. Results showed that lower molecular weight zwitterionic pSBMA-catechol conjugate led to lower contact angles and better nonfouling properties on PLLA films when the coating was performed in a solution containing ethanol. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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