期刊
PHARMACOGENOMICS
卷 20, 期 3, 页码 189-212出版社
FUTURE MEDICINE LTD
DOI: 10.2217/pgs-2018-0157
关键词
ACE inhibitor; cough; genetic polymorphism
资金
- National Key R&D Program of China [2016YFC0904900]
- National Natural Science Foundation of China [81673509, 81573504]
- Natural Science Foundation of Beijing Municipality [7171012]
- National Science and Technology Major Projects for 'Major New Drugs Innovation and Development' [2017ZX09304028, 2017ZX09101001]
Aim: Genetic polymorphisms may influence the incidence of angiotensin-converting enzyme (ACE) inhibitor-induced cough. This study aims to investigate this association. Methods: Ten electronic databases and PharmGKB were systematically searched. Pooled odds ratio values and their 95% CI were used to assess the association, using the random-effects model. Results: A total of 26 studies were included in the review, 17 of them were included from two separated meta-analysis (ACE I/D or BDKRB2-58T/C). Significant association was found between ACE I/DI carriers (ACE gene insertion) and ACE inhibitor-induced cough, showing racial and age differences. Conclusion: This study demonstrated that ACE I/D but not BDKRB2-58T/C polymorphism could be a predictor for the risk of ACE inhibitor-induced cough, especially in east Asians and the aged.
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