期刊
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
卷 471, 期 1, 页码 193-212出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00424-018-2239-4
关键词
Slc34; Epithelial phosphate transport; Dietary phosphate (P-i) regulation; Hormonal regulation; Post-transcriptional antisense regulation; Teleost fish; Whole genome duplication; Aquaculture
类别
资金
- Northern Counties Kidney Research Fund
Teleost fish are excellent models to study the phylogeny of the slc34 gene family, Slc34-mediated phosphate (P-i) transport and how Slc34 transporters contribute P-i homeostasis. Fish need to accumulate P-i from the diet to sustain growth. Much alike in mammals, intestinal uptake in fish is partly a paracellular and partly a Slc34-mediated transcellular process. Acute regulation of P-i balance is achieved in the kidney via a combination of Slc34-mediated secretion and/or reabsorption. A great plasticity is observed in how various species perform and combine the different processes of secretion and reabsorption. A reason for this diversity is found in one or two whole genome duplication events followed by potential gene loss; consequently, teleosts exhibit distinctly different repertoires of Slc34 transporters. Moreover, due to habitats with vastly different salinity, teleosts face the challenge of either preserving water in a hyperosmotic environment (seawater) or excreting water in hypoosmotic freshwater. An additional challenge in understanding teleost P-i homeostasis are the genome duplication and retention events that diversified peptide hormones such as parathyroid hormone and stanniocalcin. Dietary P-i and non-coding RNAs also regulate the expression of piscine Slc34 transporters. The adaptive responses of teleost Slc34 transporters to e.g. P-i diets and vitamin D are informative in the context of comparative physiology, but also relevant in applied physiology and aquaculture. In fact, P-i is essential for teleost fish growth but it also exerts significant adverse consequences if over-supplied. Thus, investigating Slc34 transporters helps tuning the physiology of commercially valuable teleost fish in a confined environment.
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