期刊
PATHOLOGY & ONCOLOGY RESEARCH
卷 26, 期 1, 页码 551-557出版社
FRONTIERS MEDIA SA
DOI: 10.1007/s12253-018-00564-2
关键词
Sonic hedgehog; Hedgehog signalling pathway; Protein expression; Western blotting; Colorectal cancer; Pancreatic cancer
Sonic hedgehog (SHH) is a secreted protein which functions in autocrine or paracrine fashion on target cells to activate hedgehog (HH) signalling cascade responsible for growth and proliferation. This study is an attempt to understand the expression dynamics of SHH protein in colon, rectal and pancreatic cancers. Protein expression of SHH was studied by Western Blotting in the histologically confirmed colon, rectum and pancreatic cancer tissue samples along with their adjacent normal tissues. Only 31.4% (11 of 35) and 26.9% (7 of 26) of colon and rectal cancer cases respectively showed an increase in SHH expression in tumours compared to 72.7% (24 of 33) of the pancreatic cancer cases when compared with their adjacent normal tissues. Our results suggest that SHH may have a strong role in the predisposition of Pancreatic cancer and could possibly be used as a diagnostic or prognostic biomarker.
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