期刊
PARKINSONISM & RELATED DISORDERS
卷 61, 期 -, 页码 144-150出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2018.10.030
关键词
Essential tremor; Epidemiology; Genetics; Endophenotype; Cognition; Mild cognitive impairment; Pre-motor
资金
- National Institutes of Health [R01 NS094607]
- National Institutes of Health: NINDS [R01 NS094607, R01 NS085136, R01 NS073872, R01 NS088257]
- Claire O'Neil Essential Tremor Research Fund (Yale University)
Background: In numerous case-control studies, essential tremor (ET) has been associated with cognitive impairment. ET is often familial. However, cognitive impairment has not been studied in family members of ET cases. Endophenotypes are measurable clinical characteristics that may be present in individuals with increased risk for disease; as such, they may be present before disease onset. We administered a global cognitive screen to first-degree relatives of ET cases (FD-ET) and age-matched controls (Co). Methods: We administered the Montreal Cognitive Assessment (MoCA) to 156 FD-ET and 73 Co, none of whom were diagnosed with ET or reported tremor. MoCA < 26 was considered suggestive of cognitive impairment. Results: FD-ET and Co were similar with respect to age (60.1 +/- 8.3 vs. 60.9 +/- 7.4 years) and numerous demographic factors. FD-ET and Co also had similar MoCA scores; however, 34 of 156 (21.8%) FD-ET had a MoCA score < 26 vs only 5 (6.9%) of 73 Co (p = 0.004). In a univariate logistic regression model, FD-ET were 3.79 times more likely to have a low (< 26) MoCA than were Co (odds ratio = 3.79, p = 0.008). In a multivariate logistic regression model, adjusting for age and other covariates, FD-ET were 4.83 times more likely to have a low MoCA than were Co (odds ratio = 4.83, p = 0.003). Conclusion: More FD-ET had low MoCA scores when compared with Co. These data provide additional support for the scientific notions that (1) cognitive difficulties are a disease-associated feature of ET and (2) there may be a pre-tremor phase of illness in ET.
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