期刊
OSTEOPOROSIS INTERNATIONAL
卷 30, 期 2, 页码 267-276出版社
SPRINGER LONDON LTD
DOI: 10.1007/s00198-018-04822-6
关键词
BMSCs; Osteoblasts; Osteoclasts; Osteocytes; Osteoporosis; PEMFs
资金
- National Natural ScienceFoundation of China [81572236]
- Chengdu Bureau ofScience and Technology [2015-HM02-00042-SF]
Osteoporosis (OP) is considered to be a well-defined disease which results in high morbidity and mortality. In patients diagnosed with OP, low bone mass and fragile bone strength have been demonstrated to significantly increase risk of fragility fractures. To date, various anabolic and antiresorptive therapies have been applied to maintain healthy bone mass and strength. Pulsed electromagnetic fields (PEMFs) are employed to treat patients suffering from delayed fracture healing and nonunions. Although PEMFs stimulate osteoblastogenesis, suppress osteoclastogenesis, and influence the activity of bone marrow mesenchymal stem cells (BMSCs) and osteocytes, ultimately leading to retention of bone mass and strength. However, whether PEMFs could be taken into clinical use to treat OP is still unknown. Furthermore, the deeper signaling pathways underlying the way in which PEMFs influence OP remain unclear.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据