期刊
ORGANIC LETTERS
卷 20, 期 21, 页码 6832-6835出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02949
关键词
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资金
- University of Delaware
- NSF [CAREER CHE1254360, NSF CHE0421224, CHE1229234, CHE0840401, CHE1048367, NIH P20GM103541, P30GM110758, S10RR026962, S10OD016267]
- NIH [NSF CHE0421224, CHE1229234, CHE0840401, CHE1048367, NIH P20GM103541, P30GM110758, S10RR026962, S10OD016267]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P20GM104316, P30GM110758] Funding Source: NIH RePORTER
The direct borylation of disubstituted alkenes is reported. These conditions allow for the conversion of a variety 1,1- and 1,2-disubstituted alkenes to trisubstituted alkenyl boronic esters with outstanding yields and excellent E/Z selectivities. The utility of this reaction has been demonstrated with several downstream functionalization reactions, which allow access to diverse, stereodefined, functionalized olefins. Mechanistic studies are consistent with a boryl-Heck pathway.
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