期刊
ORGANIC LETTERS
卷 20, 期 22, 页码 7039-7043出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02982
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资金
- National Young Thousand Talents Plan
- National Natural Science Foundation of China [21871150]
- Fundamental Research Funds for Central University
- State Key Laboratory of Elemento-organic Chemistry and College of Chemistry of Nankai University
The gold(I)-catalyzed enantioselective hydroetherification of alkynes was achieved via desymmetrization of prochiral bisphenols bearing P-stereogenic centers. (S)-DTBM-Segphos(AuCl)(2)/AgNTf2 proved to be a highly efficient catalyst system for this transformation, affording P-chiral cyclic phosphine oxides in good yields with high enantioselectivities (with up to 99% ee). The same catalyst system allowed for the enantioselective desymmetrization of dialkynes. Synthetic transformations of the cyclization products afforded other P-chiral molecules with high enantiospecificity.
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