期刊
ORGANIC LETTERS
卷 21, 期 2, 页码 387-392出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b03542
关键词
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资金
- National Natural Science Foundation of Hunan Province [2018JJ2389]
- National Natural Science Foundation of China [21402168]
- Project of Innovation Team of the Ministry of Education [IRT_17R90]
A simple catalyst- and promoter-free protocol has been developed for the transamidation of weakly nucleophilic aromatic amines with formamide derivatives and low-reactivity tertiary amides with aliphatic amines. This strategy is advantageous because no catalyst or promoters are needed, no additives are required, separation and purification is easy, and the reaction is scalable. Significantly, this strategy was further applied to synthesize several pharmaceutical molecules on a gram scale, and excellent yields were achieved.
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